Humanized Monoclonal Antibodies as a Synthetic Serum Alternative
SERION antibodies
As a highly reliable and readily available alternative to human serum, SERION Immunologics offers humanized monoclonal antibodies.
These monoclonal antibodies have been extensively tested for performance in comparison to human disease state sera, showing that the antibodies behave similarly to sera. Therefore, they can be optimally used for preparation of calibrators, controls and standards.
The monoclonal antibodies are offered in two different matrices. The original product line is provided as a cell culture supernatant packaged in quantities ranging from 1 mL to 1 L quantities. The new generation of antibodies is available in IgG-depleted and delipidized human serum matrix with 100 μg up to 25 mg packaging sizes. Production lots are usually offered with a concentration range between 100 μg/mL and 150 μg/mL.
Test samples can be offered free of charge, please let us know .
Features and benefits:
- High affinity
- High specificity
- Industrial batch sizes
- Stable, permanent availability
- Constant quality and performance
Technology:
SERION antibodies are produced in transgenic mice by replacing the mouse sequence of the heavy chain constant region (IgM locus) with the corresponding human sequence. After immunization with the antigen of interest, generated antibody clones are cultivated by standard hybridoma techniques. These consist of the human constant region of the heavy chain, mouse variable region of the heavy chain and mouse light chain. The human constant region of the heavy chain can be directly recognized by the anti-human conjugate, which is used in numerous in-vitro diagnostic assays. The production process is carried out in collaboration with with Bcell Design (Illkirch-Graffenstaden, France).
A cooperation with
