Jo-1

Anti-Jo-1 antibodies are highly specific markers for the diagnosis of idiopathic inflammatory myopathies and ASS (Antisynthetase syndrome). Jo-1 catalyzes the formation of aminoacyl-tRNAs, which are necessary for protein synthesis at the ribosomes.

Idiopathic inflammatory myopathies such as polymyositis and dermatomyositis are a group of diseases characterized by muscle weakness, inflammation of muscles (myositis), and in some types, muscle pain (myalgia).The manifestations of these conditions may include skin issues or affect other organs. Additionally, systemic symptoms like weight loss, fatigue, and low-grade fever can emerge. Laboratory testing comprises screening for autoantibodies, such as anti-Jo-1, anti-HMGCR, or anti-TIF1 antibodies.

Antisynthetase syndrome is an autoimmune disease characterized by inflammatory myositis, interstitial lung disease, mechanic's hands, Raynaud's phenomenon, arthritis and fever. The term "mechanic's hands" describes the roughening and cracking of the skin on the lateral sides of the fingers. Pulmonary involvement is an important factor in morbidity and mortality. It is seen in 70–100% of patients with antisynthetase syndrome. Diagnosis is performed by a combination of radiologic features, clinical criteria, and identification of Jo-1 antibodies.

Virion\Serion’s Jo-1 Antigen (BA503R01) is recombinantly produced in E. coli and highly purified via Strep-tag affinity chromatography, which guarantees high quality and availability. 

Please let us know if you are interested in 0.25 mg test sample.